Cambridge Healthtech Institute’s 12th Annual

Analytical Characterisation of Biotherapeutics

Expanding the Analytical Toolkit for New Modalities

12 November 2025


Cambridge Healthtech Institute’s 12th Annual Analytical Characterisation of Biotherapeutics conference explores innovative analytical techniques for biotherapeutics characterisation. Sessions will cover advanced mass spectrometry innovations including top-down LC-MS and multi-attribute methods, high-throughput electrophoresis, and analytical strategies for novel modalities such as multispecifics, ADCs, and nanobodies, etc. Topics on biophysical and bioanalytical characterisation and computational approaches including AI-driven analytics for complex biologics will also be examined. This conference aims to provide actionable insights to enhance your analytical strategies and accelerate biotherapeutics development.

Coverage will include, but is not limited to:

Advanced Analytical Techniques and Mass Spectrometry Innovations

  • Intact top-down LC-MS for complex biotherapeutics
  • Multi-Attribute Methods (MAM) for complex biotherapeutics and fusion proteins
  • High-throughput capillary electrophoresis (CE-SDS, SEC) for characterisation
  • Automation in analytical workflows
  • Advances in real-time release testing (PAT, MS-based MAM)
  • Implementation of MS for GMP use and QC

Structural and Biophysical Characterization Challenges of Novel Modalities

  • Analytical platform adaptation for multispecific formats
  • Characterisation strategies for ADCs, immunoconjugates, radiotherapies, peptides, oligonucleotides and RNA-based therapies
  • Higher-order structure analysis via native MS, NMR, and SAXS
  • Stability and degradation pathways of novel biologics

Bioanalytical Strategies for in vitro/in vivo Stability and PK Characterization

  • ADCs/multispecifics
  • Immunoassays/Potency assays

Computational and AI-Driven Analytics

  • AI-guided de novo peptide sequencing for antibody profiling
  • Predictive immunogenicity assays for product and impurity characterisation
  • Integration of machine learning in biophysical and structural analysis

The deadline for priority consideration is 28 March 2025.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation:


For more details on the conference, please contact:

Mimi Langley
Executive Director, Conferences
Cambridge Healthtech Institute
Email: mlangley@healthtech.com

For sponsorship information, please contact:

Companies A-K
Jason Gerardi
Sr. Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5452
Email: jgerardi@healthtech.com

Companies L-Z
Ashley Parsons
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1340
Email: ashleyparsons@healthtech.com