Cambridge Healthtech Institute’s 4th Annual
Antibodies Against Membrane Protein Targets
New Strategies and Technologies to Accelerate the Development of Biotherapeutics against Complex GPCR and lon Channel Targets
13 November 2025
The 2025 Antibodies Against Membrane Proteins conference will explore the latest strategies for developing antibodies targeting complex membrane proteins, a crucial area for therapeutic innovation. This conference will highlight advances in mechanistic understanding across diverse disease areas, including cancer, neuroscience, and metabolic disorders, with a focus on overcoming long-standing challenges in drug discovery. Attendees will explore the integration of AI/ML tools in this space and discuss cutting-edge screening methods, structural analysis, and novel approaches for addressing resistance mechanisms. By bringing together experts in antibody engineering, structural biology, and computational modeling, this conference aims to advance the field toward more precise and effective therapies.
Coverage will include, but is not limited to:
Emerging Modalities for Membrane Protein Targets
- Biparatopic antibodies
- Lipidated ligands
- Masking and conditional activation
- mRNA
- Multispecifics and novel conjugations
- Protein degraders
Targeting Challenges
- Adhesion GPCRs
- GPCR-related autoantibodies
- Ion channels
- Transporters
Strategies and Technologies for Functional Assays
- Application case studies
- Cellular imaging
- Demonstrating efficacy in organoid systems
- Electrophysiology for ion channel targets
- Radioactive ligands for transporter targets
- Receptor-based reporter assays
Discovery Platforms and Antigen Strategies
- Best practices for internal development of membrane mimetics
- Functional reagents
- Generalisation and validation of antigen platforms
- Matching platforms to problems
Computational Design and Optimisation
- Benchmarking AI/ML discovery/design against conventional methods
- Case studies of de novo design
- Tools for developability prediction and biotherapeutic optimisation
- Training data acquisition and generation
Structural Biology Applications
- High-throughput image analysis
- Opportunities and limitations of AF3 and computational structure prediction
- The convergence of cryoEM and AI/ML for analysis and prediction
- When do you really need a structure?
The deadline for priority consideration is 28 March 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: