Cambridge Healthtech Institute’s 10th Annual
Engineering Antibodies & Beyond
Designing the Next Best-in-Class Biologics
12 November 2025
Cambridge Healthtech Institute’s 10th Annual Engineering Antibodies & Beyond conference brings together leaders in protein engineering to explore cutting-edge advances in the architecture and design of next-generation constructs and emerging therapeutic formats. Attendees will gain insights into strategies to improve function, specificity, selectivity, and stability, leading to better safety and efficacy profiles for new modalities including bi/multispecifics, nanobodies, peptides, alternative scaffolds, brain shuttled-antibodies and more. This conference will present how today's engineering innovations are reshaping tomorrow's biologics landscape.
Coverage will include, but is not limited to:
IMPROVING FUNCTION, SPECIFICITY, AND TARGET SELECTIVITY OF NEXT GENERATION FORMATS
- Improving Specificity with Dual Targeting
- Masking/Conditional Activation at the Tumour / Prodrugs (pH, ATP, proteases, chain exchange)
- VHH Humanisation
- AI-Powered Protein Design
- Therapeutic Window Improvement
- Engineering for Improved Pharmacokinetics
ENGINEERING FOR AUTO-IMMUNE DISEASES
- Complement Inhibition
- Cytokine Targeting
- FcRn Inhibition
- IgG Depletion
ENGINEERING FOR CNS DELIVERY - CROSSING THE BLOOD BRAIN BARRIER
- Transferrin Receptor (TfR1) Brain Shuttles
- Alternative BBB Receptors Beyond TfR
- Oligonucleotide-Antibody Conjugates for CNS Disorders
- Bispecific Approaches for Enhanced Brain Penetration (TfR/CD98 Combinations)
- Delivery of Antibodies Against Amyloid-Beta
The deadline for priority consideration is 28 March 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: