Cambridge Healthtech Institute’s 16th Annual
Optimisation & Developability
Improving Candidate Selection Leading to Clinical Success
11 November 2025
Cambridge Healthtech Institute’s 16th Annual Optimisation & Developability conference presents advanced methodologies for developing and optimising therapeutic biologics for clinical success. Sessions covered include developability screening using structure-function modelling and AI-enhanced biophysical techniques, engineering strategies for improved pharmacokinetics and half-life extension, computational approaches for biologics optimisation and formulation prediction, and immunogenicity risk assessment for novel modalities. Learn how AI and in silico modelling are combined with experimental methods to revolutionise the way we assess and select candidates for clinical development, and to prevent late-stage failures.
Coverage will include, but is not limited to:
Advances in Developability Screening and Liabilities Prediction: from Experimental, Computational to Machine Learning Approaches
- Developability assessments of emerging formats - VHHs, nanobodies, mRNAs and more
- In silico tools for multi-parameter developability assessment: aggregation, viscosity, hydrophobicity, etc.
- Use of ML models to predict liabilities (deamidation, isomerization, oxidation, viscosity)
- Early stage predictive analytics for formulation optimisation
- Predictive algorithms for viscosity at high concentration for bisp antibodies and mAbs
- Integration of ML with wet-lab based analysis and structure data
Optimisation of Functional Attributes
- Binding affinity and specificity
- Fc receptor binding characteristics
- Complement activation
- Glysosylation profile
- Disulfide bond integrity
In silico & AI-Powered Biologics Optimisation and Immunogenicity Risk Assessment
- Automation in biologics characterisation and screening
- AI/ML for manufacturability and stability assessment
- Predictive modelling for PK/PD and bioavailability
- Early-stage predictive analytics for formulation optimisation
- Computational tools for immunogenicity assessment and prediction
- In silico risk assessment and mitigation strategies for new modalities
The deadline for priority consideration is 28 March 2025.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: